American Board of Internal Medicine (ABIM) Certification Practice Exam

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How frequently is isoniazid administered when used with rifapentine for latent TB treatment?

  1. Daily

  2. Once weekly

  3. Twice weekly

  4. Monthly

The correct answer is: Once weekly

Isoniazid, when used in combination with rifapentine for the treatment of latent tuberculosis (TB) infection, is administered once weekly. This regimen is part of an effective short-course treatment strategy. The combination of isoniazid and rifapentine is typically part of a 12-week program where patients receive isoniazid and rifapentine together once a week for 12 doses. This once-weekly administration is designed for better adherence compared to daily regimens, while still providing effective treatment. The strategy utilizes the synergy between the two medications, addressing the latent TB infection with a regimen that is both efficient and easier for patients to complete. While daily administration might be used for other treatments or certain cases of active TB, it is not part of the recommended schedule for latent TB management with rifapentine. Similarly, administering the medications twice weekly or monthly would not align with the established guidelines for this specific treatment regimen, which emphasizes the importance of optimizing patient adherence through a more convenient dosing schedule.

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