American Board of Internal Medicine (ABIM) Certification Practice Exam

What is the suggested interval for measuring serum aminotransferase levels in patients on interferon beta?

1. 1 to 2 months

2. 3 to 6 months

3. 6 to 12 months

4. Every month

The correct answer is: 3 to 6 months

The suggested interval for measuring serum aminotransferase levels in patients on interferon beta therapy is 3 to 6 months. This recommendation stems from the potential for hepatotoxicity associated with interferon beta, leading to elevated liver enzymes. Monitoring these levels within this timeframe allows for the timely identification of any liver function abnormalities while minimizing unnecessary frequent testing. Testing every month, while thorough, may not be necessary and could lead to increased patient burden and healthcare costs without significant benefit, as serious liver issues typically manifest over a longer period. Likewise, intervals longer than 6 months may delay the diagnosis of hepatotoxicity, making it important for healthcare providers to strike a balance between vigilance and practicality in monitoring liver health during treatment with interferon beta.