American Board of Internal Medicine (ABIM) Certification Practice Exam

What medication is prescribed for the treatment of amyotrophic lateral sclerosis?

1. Riluzole

2. Gabapentin

3. Baclofen

4. Dantrolene

The correct answer is: Riluzole

Riluzole is the medication specifically approved for the treatment of amyotrophic lateral sclerosis (ALS). It works by inhibiting the release of glutamate, a neurotransmitter that, in excess, can contribute to neuronal damage. By reducing the levels of glutamate, riluzole helps to slow down the progression of ALS and can prolong survival in patients with this condition. Other medications listed serve different purposes: Gabapentin is primarily used for neuropathic pain and seizure disorders, Baclofen is a muscle relaxant used to treat spasticity, and Dantrolene is used for muscle spasticity and, more specifically, is utilized in malignant hyperthermia. While these medications may be part of the management of symptoms associated with ALS, they do not address the underlying disease process or have a direct impact on survival or disease progression in ALS.