American Board of Internal Medicine (ABIM) Certification Practice Exam

Which of the following is a common treatment for muscle spasticity in multiple sclerosis?

1. Gabapentin

2. Tizanidine

3. Both Gabapentin and Tizanidine

4. None of the above

The correct answer is: Both Gabapentin and Tizanidine

Tizanidine is often used as a first-line treatment for muscle spasticity in patients with multiple sclerosis due to its effectiveness as a muscle relaxant. It works by acting on the central nervous system to reduce muscle tone. Gabapentin, primarily known for its use in neuropathic pain, can also be beneficial in managing muscle spasticity because it modulates neurotransmitter release, thereby contributing to muscle relaxation and spasticity reduction. Using both Tizanidine and Gabapentin together can provide a synergistic effect, addressing different aspects of spasticity management. This combination can be more effective in alleviating symptoms than using either medication alone, making it a common treatment strategy for muscle spasticity in multiple sclerosis. Therefore, recognizing the role that both medications play in addressing spasticity provides a comprehensive approach to management in this patient population.