American Board of Internal Medicine (ABIM) Certification Practice Exam

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Why might vWF antigen and activity levels need to be measured repeatedly in suspected vWD cases?

They always remain constant
Because levels fluctuate based on various factors
To ensure proper treatment is given
For compatibility in transfusion

The correct answer is: Because levels fluctuate based on various factors

In cases of suspected von Willebrand Disease (vWD), it is essential to measure vWF antigen and activity levels repeatedly because these levels can fluctuate based on various factors. These factors include physiological variations, such as stress, hormonal changes, and acute illnesses, as well as possible recent surgical procedures that can temporarily alter these measurements. Continuous monitoring allows for a more accurate assessment of the patient's condition over time, providing a clearer picture of their vWF levels. This is critical for diagnosing vWD, determining its subtype, and guiding appropriate treatment plans. As vWF levels are not static and can vary significantly, repeated testing helps in understanding the dynamic nature of the disorder and managing the patient's care effectively.