American Board of Internal Medicine (ABIM) Certification Practice Exam

Which epilepsy syndrome is often considered a life-long condition requiring continuous treatment?

1. Wilde syndrome

2. Juvenile Myoclonic Epilepsy (JME)

3. West syndrome

4. Rasmussen's syndrome

The correct answer is: Juvenile Myoclonic Epilepsy (JME)

Juvenile Myoclonic Epilepsy (JME) is indeed a syndrome commonly recognized as a life-long condition requiring continuous treatment. JME typically begins in adolescence or early adulthood and is characterized by myoclonic jerks, generalized tonic-clonic seizures, and absence seizures. The necessity for lifelong treatment stems from the chronic nature of the syndrome; seizures often persist throughout a person’s life despite treatment. While many patients experience remission or have fewer seizures with treatment, they generally need to remain on anti-seizure medications to prevent the recurrence of seizures. Regular follow-ups and adherence to therapy are crucial in managing this condition effectively. In contrast, other syndromes listed have different prognoses and treatment requirements. For instance, West syndrome typically occurs in infancy and may remit with treatment, whereas Rasmussen's syndrome can lead to progressive neurological decline, often requiring surgical intervention. Wilde syndrome, also not widely recognized, does not fit the typical epileptic syndrome standard.